摘要
目的:探讨醒脑静注射液与乌司他丁联合应用于脓毒症中的治疗效果.方法:回顾性分析150例脓毒症患者的临床资料,参照用药方案不同将其划分为单一组(在基础治疗联合乌司他丁注射)和联合组(基础治疗加用乌司他丁注射联合醒脑静治疗),各75例.比较治疗前后两组患者的CRP(C反应蛋白)水平、IL-6(白细胞介素6)和TNF-a(血清炎症因子肿瘤坏死因子a)指标水平以及住院时间、机械通气时间、28d病死率.结果:治疗后,相对于单一组来说,联合组患者的CRP、IL-6、TNF-a水平、28d病死率明显较低(P ＜ 0.0
Abstract
Objective To investigate the therapeutic effect of intravenous injection and ulinastatin in sepsis.Methods The clinical data of 150 sepsis patients were retrospectively analyzed, and they were divided into a single group (in basic treatment combined with ulinastatin injection) and a combination group (basic treatment combined with ulinastatin injection), with 75 cases each.To compare CRP (C reactive protein), IL-6 (interleukin 6) and TNF-a (serum inflammatory cytokine tumor necrosis factor A), length of hospitalization, duration of mechanical ventilation, and 28d mortality before and after treatment.RESULTS After treatment, CRP, IL-6, TNF-a, and 28d mortality were significantly lower (P ＜0.05), and mechanical ventilation were significantly shorter (P ＜0.05).Conclusion The combined treatment of ulinastatin and Xingenjing injection can effectively reduce the level of inflammatory factors, shorten the hospital time and improve the survival rate of sepsis patients.
万方数据