Surgery is the main method to treat thyroid diseases, but because of the trauma of surgery on the patient is relatively large, so the patient may appear panic, anxiety and other emotions, the patient''s mood changes will lead to the release of physiological hormones, will have a greater impact on the patient''s surgical effect.In particular, the emotional changes during the operation will lead to the fluctuation of vital signs, increased heart rate and blood pressure, which will affect the surgical safety of patients and also affect the recovery of patients.Therefore, psychological guidance is needed to improve the patient''s mood and reduce the impact on the disease during the operation of thyroid patients.This paper is to take personalized psychological nursing measures for patients with thyroid surgery, to provide more help for patient care, improve the psychological state of patients, promote the stability of patients.