Objective To explore the preventive effect of respiratory tract nursing on ventilator-associated pneumonia in patients with severe craniocerebral injury after surgery.Methods: From March 2020 to May 2022, a total of 100 patients with severe craniocerebral injury were selected for analysis and study.They were divided into two groups by random number table, namely, 50 patients in the control group and 50 patients in the observation group.The average times of sputum aspiration, the average amount of sputum excretion per day, and nursing satisfaction.Results: The infection rate and mortality rate in the control group were higher than those in the observation group (P<0.05).All clinical indexes in the observation group were better than those in the control group (P<0.05).Compared with the control group, the nursing satisfaction of the observation group was significantly higher (P<0.05).Conclusion: Applying respiratory tract nursing to patients with severe craniocerebral injury undergoing surgical treatment can play a role in improving the effect, sputum suction times and carbon emission.