Objective To improve the operating room nursing safety management ability in the operating room detail nursing application value analysis.Methods A total of 100 subjects were included in this study, all of whom were scheduled to receive surgical treatment in our hospital.The collection period of the enrolled subjects was from January 2021 to December 2021.A total of 50 patients who received surgical treatment from January 2021 to June 2021 were included in group A, and routine nursing was implemented in the operating room at this stage.In the later stage, the work was optimized to implement the detailed nursing model in the operating room, and 50 cases of surgical treatment collected from June 2021 to December 2021 were included in group B.To compare the effects of different nursing modes on nursing safety in operating room.Results Compared with group A, the nursing quality score of operating room in group B was relatively higher, the nursing comfort of patients and the excellent and good rate of satisfaction with operating room nursing work were relatively higher (P<0.05).Conclusions The application of detail nursing model in operating room nursing work can promote the overall improvement of work quality and efficiency, can refine the work, ensure the effect and safety of surgery, improve the comfort and satisfaction of surgery patients, the application value is a high quality nursing model, worthy of promotion.