Objective To observe the clinical effect of continuous subcutaneous infusion of insulin aspartate in patients with gestational diabetes mellitus.Methods: A total of 96 patients with gestational diabetes mellitus were selected from our hospital from April 2020 to May 2022.According to the double-blind method, the patients were divided into two groups, namely the study group and the control group, 48 cases in each group.The control group was treated with biosynthetic insulin injection, and the discussion group was treated with continuous subcutaneous insulin aspartate infusion. The blood glucose level, clinical indexes, pregnancy outcomes, complications and delivery methods were compared between the two groups.Results: After treatment, the blood glucose level of the discussion group was better than that of the control group.Compared with the control group, the clinical indexes of the discussion group were better after treatment.The pregnancy outcome of the control group was worse than that of the discussion group.The complication rate of the study group was lower than that of the control group.The rate of natural childbirth in control group was lower than that in study group (P<0.05).Conclusions: Continuous subcutaneous infusion of insulin aspartate in the treatment of gestational diabetes can not only improve the blood glucose level and clinical indicators of patients, but also optimize the pregnancy outcome, promote the reduction of complications and increase the rate of natural delivery.