Objective To explore the effect of voriconazole and amphotericin B in the treatment of acute lymphoblastic leukemia combined with invasive fungal infection.Methods: In this study, 50 patients with acute lymphoblastic leukemia complicated with invasive fungal infection were selected. From January 2020 to December 2022,25 patients in the control group were treated with amphotericin B, and 25 patients in the study group were treated with voriconazole.Then.Results: The response rate in the study group was 96.00％ (24 / 25), higher than the control group 72.00％ (18 / 25) (P＜0.05); the incidence of adverse response in the study group was 12.00％ (3 / 25) and lower than the control group 28.00％ (7 / 25) (P＜0.05). Conclusion: For patients with acute lymphoblastic leukemia combined with invasive fungal infection, voriconazole treatment can strengthen the clinical treatment efficiency, and reduce the incidence of adverse reactions, with high clinical value.
关键词
急性淋巴细胞白血病合并侵入性真菌感染/伏立康唑/两性霉素B
Key words
acute lymphoblastic leukemia combined with invasive fungal infection/voriconazole/amphotericin B
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