Objective To explore the quality of combined humanistic care and cluster nursing measures during the postoperative rehabilitation care of patients with esophageal cancer.Methods: The 84 patients included in the study group this time were all confirmed esophageal cancer patients who received surgical treatment in our hospital from August 2021 to November 2022.Based on the random number table method, 42 patients were assigned to the control group of humanistic care nursing and the observation group of combined cluster nursing, according to which, the nursing effect was observed and recorded, and the related indicators were compared and analyzed after the end of nursing.Results: Before nursing, there was no difference between the two groups in nutritional status related indicators (P>0.05); After nursing, there was a downward trend, but the observation group was significantly higher than the control group (P<0.05).The incidence of complications in the observation group was significantly lower than that in the control group (P<0.05).Conclusion: The combination of humanistic care and intensive care measures during the post operation rehabilitation care of patients with esophageal cancer is conducive to improving the nutritional status of patients, reducing the incidence of postoperative complications, and promoting the rapid recovery of patients.It is worth popularizing.