Objective To analyze the effect of compound metronidazole vaginal suppository in the treatment of vaginitis.Methods From March 2021 to November 2022, a total of 60 patients with vaginitis were selected.The study subjects were randomly divided into 30 cases in the control group and 30 cases in the observation group.The control group was treated with metronidazole tablets, and the compound metronidazole vaginal suppository was applied to the observation group to compare the therapeutic effect.Results Compared with the control group, the total effective rate of the observation group was significantly higher (P<0.05).Conclusion: The clinical effect of using compound metronidazole vaginal suppository during the treatment of vaginitis is prominent, and it is worth popularizing.