Objective To analyze the value of ticagrelor with emergency PCI in the treatment of acute myocardial infarction. Methods The study subjects enrolled 200 patients with acute myocardial infarction admitted to the emergency department of our hospital, randomly divided into reference group (clopidogrel + emergency PCI) and observation group (ticagrelor + emergency PCI, 100 each). Patients were followed up for six months to compare the myocardial enzyme profile, the levels of inflammatory factors and the occurrence of cardiovascular adverse events between the two groups. Results After treatment, the levels of IL-6, TNF-a and other inflammatory factors were reduced in the two groups, and the incidence of cardiovascular adverse events and myocardial enzyme level in the observation group were significantly lower than that of the reference group, and the difference of data between the groups was significant (P <0.05). Conclusion Ticagrelor and emergency PCI for acute myocardial infarction is effective and beneficial.