Gastrointestinal bleeding is a common gastrointestinal disease. According to incomplete statistics, approximately 1.5 million people in the world die from gastrointestinal bleeding each year. Objective: This article aims to improve the cure ability of the disease by studying the nursing intervention of patients with gastrointestinal bleeding. METHODS: This article will select 200 people who were admitted to hospital for gastrointestinal bleeding during the four years from 2013 to 2017. The study time ranged from January 2013 to May 2017. Randomly selected and able to 200 cases. There was no significant difference in symptoms, which was mainly reflected in the fact that the gastrointestinal bleeding caused by gastrointestinal diseases and the discovery time were within the controllable range, which ensured the authenticity of the sample invariants. On this basis, 200 people were randomly selected to be divided into observation groups, and 100 were divided into control groups. The control group was treated with traditional methods while the observation group was 100 patients. Graded nursing interventions were used. Rehabilitative treatment of the disease, comparing patients with two different care methods in the digestive tract bleeding disease, rehabilitation progress and psychological conditions during treatment, with statistically significant differences (P> 0.05). Results: According to the statistical analysis results, a feasible strategy for clinical nursing intervention was proposed.