Ni Haiwen's clinical thinking mode of malignant lymphoma based on the theory of"cancer toxin-state target"
Malignant lymphoma is a group of malignant tumors originating from lymph nodes or other lymphohematopoietic tissues.Delivering an accurate stratification and a targeted treatment is its main treatment mode in the new drug era,while managing drug resistance recurrence,complications,and toxic and side effects is its main challenge in the real world,and reducing toxicity and increasing efficiency is the advantage and goal of the integrated Chinese and western medicine.The cancer toxin pathogenesis theory is a cancer differentiation and treatment system advocated by Zhou Zhongying,a master of traditional Chinese medicine,while the"state-target theory"is a modern differentiation and treatment model of traditional Chinese medicine proposed by Academician Tong Xiaolin,which takes"disease as a reference,states as a basis,symptoms as targets,causes as a priority,and prognosis as evidence".The syndrome differentiation and treatment of traditional Chinese medicine is manipulated to"regulate states in a macrocosmic manner",while modern medicine is applied to"target the microcosmic symptoms",so that a higher level of integration of traditional Chinese and western medicine eventually be achieved.Professor Ni Haiwen,guiding his clinical practice with the cancer toxin pathogenesis theory,combining the core concept of state-target theory,innovatively proposes a new integrated clinical differentiation and treatment mode of lymphoma based on the combination of"cancer toxin-state target".The new mode strictly follows the core pathogenesis of"deficiency of vital qi due to cancer toxin",and uses Xiaoai Jiedu Fang as the core target prescription to strengthen the body resistance and resist cancer toxin throughout the whole process.Given cancer toxin prone to damage vital qi,the new mode is supposed to grasp the law of the conflict between healthy qi and pathogenic factors,and their rise and fall,and to distinguish the changes in different stages.As for the fact that cancer toxin is usually mixed with multiple factors,such as"phlegm,heat,blood stasis,and deficiency",the mode is supposed to observe the pathogenesis closely,and to use drugs respectively to resolve phlegm,clear heat,remove blood stasis,benefit qi,and nourish yin to regulate the abnormal states.In the new mode,targeted drugs are applied to the common symptoms of lymphoma,the progress of molecular mechanism is utilized,and corresponding"targeted"drugs are delivered precisely to key targets.The study is expected to construct a"cancer toxin-state target"mode for lymphoma differentiation and treatment in the new drug era,so as to"regulate states and targets simultaneously,combine the disease with its symptoms",and optimize the clinical practice of lymphoma with integrated Chinese and western medicine.
state-target theorypathogenesis of cancer toxinmalignant lymphomaclinical thinking mode
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