Study on the advantages of Qingbai Kuijie Decoction by enema in the treatment of ulcerative colitis
Objective To study the effect of Qingbai Kuijie Decoction by enema in the treatment of ulcerative colitis and its influence on disease-related factors.Methods A total of 78 patients with ulcerative colitis admitted to our hospital from December 2020 to December 2022 were divided into the control group(n=39)and the experimental group(n=39),based on the random number table method.The control group was treated with mesalazine sustained-release granules,while the experimental group was treated with Qingbai Kuijie Decoction by enema on the basis of that.Fourteen days constituted a course of treatment,and both groups received continuously two courses.The clinical efficacy after 2 courses of treatment,TCM syndrome scores,levels of intestinal flora,immune function,serum interleukin(IL-6),intestinal fatty acid binding protein(I-FABP),perinuclear anti-neutrophil antibody(p-ANCA)and C-reactive protein(CRP)at different time points(before and after 2 courses of treatment)of the two groups were compared.Results The total effective rate of the experimental group(92.31%)was significantly higher than that of the control group(71.79%)(P<0.05).After 2 courses of treatment,the TCM syndrome scores,Th17 cell proportions,levels of serum IL-6,CRP,I-FABP and p-ANCA showed a decreasing trend in both groups(P<0.05),and the experimental group was lower than the control group(P<0.05).After two courses of treatment,the numbers of lactobacillus and bifidobacterium increased in both groups,and the numbers were significantly bigger in the experimental group than those in the control group(P<0.05).After two courses of treatment,the number of escherichia coli decreased in both groups,and the number was significantly smaller in the experimental group than that in the control group(P<0.05).The proportions of Treg cells,the levels of serum CD3+ and CD4+ showed an increasing trend in both groups compared with before treatment,and the experimental group was significantly higher than the control group(P<0.05).Conclusion Qingbai Kuijie Decoction by enema can regulate the changes of intestinal flora in patients with ulcerative colitis,and can auxiliarly alleviate inflammatory injury and improve immune function.
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