Effects of the Fenxiao Zouxie method on the metabolism,stress and inflammatory state in patients with metabolic syndrome
Objective To explore the clinical efficacy of the"Fenxiao Zouxie method"in the treatment of metabolic syndrome(MS)by Lu Zhizheng,a Chinese medicine master,and its influence on the metabolism,stress and inflammatory status in patients with the syndrome of dampness-heat.Methods From March 2018 to April 2020,200 MS patients with the dampness-heat pattern in our hospital were randomly divided into the control group(treated with pioglitazone hydrochloride)and the experimental group(treated with Qushi Jiangzhuo Decoction).The therapeutic effects of the two groups were compared after treatment.The traditional Chinese medicine symptom scores,metabolism related indicators[triglyceride(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),alanine transaminase(ALT),glutamic transaminase(AST),fasting blood glucose(FBG),uric acid(UA)],stress and inflammation related indicators[glutathione peroxidase(GSH-Px),total antioxidant capacity(T-AOC),myeloperoxidase(MPO),malondialdehyde(MDA),interleukin-6(IL-6),human monocyte chemotactic protein-1(MCP-1),adiponectin(ADP)and lipoprotein(LP)]were collected and compared between the two groups before and after treatment.Results Compared with the control group,the total effective rate of the experimental group was significantly increased(P<0.05).Before treatment,there was no statistically significant difference in main symptom score,secondary symptom score,total score of traditional Chinese medicine symptoms,metabolism,stress and inflammation related indicators between the two groups(P>0.05).After treatment,compared with the control group,the main symptom score,secondary symptom score,total score of traditional Chinese medicine symptoms,levels of TG,TC,ALT,FBG,UA,MPO,MDA,IL-6,MCP-1,LP in the experimental group were significantly decreased(P<0.05),while the levels of HDL-C,GSH-Px,T-AOC,and ADP were increased(P<0.05).Conclusion Lu Zhizheng's"Fenxiao Zouxie method"can be used in the treatment of MS with the dampness-heat syndrome,which may help improve their symptoms,metabolism,stress and inflammatory state,and is worthy of clinical promotion.
metabolic syndromeFenxiao Zouxie method(method for elimination of pathogens through purgation and diuresis)Qushi Jiangzhuo Decoctionmetabolismstressinflammation
万方数据
维普
