Study on the mechanisms of treating depression rats by regulating the neurotransmitter and cortisol content with Mongolian medicine warming acupuncture
Objective To observe the effects of Mongolian medicine warming acupuncture on the content of central amino acid neurotransmitters in rats with a depressive disorder,explore its mechanisms on treating the disease,and observe its effect in the regulation of anxiety symptoms in rats under stress conditions.Methods A total of 45 clean SD rats were randomly divided into an acupuncture group,a western medicine group and a normal saline group.Chronic unpredictable mild stress(CUMS)was used to establish a rat depression model.Their body weights were recorded at 0h,24h,48h and 72h,respectively,and then the central amino acid neurotransmitters were detected by the high performance liquid chromatography fluorescence detection method,and their blood samples were collected to detect the changes in serum cortisol.Results After treatment,the levels of γ-aminobutyric acid(GABA)in hippocampus and hypothalamus of depression model rats were significantly lower in the warming acupuncture group than those in the normal saline group(P<0.01,P<0.05).The contents of glutamate in hippocampus and hypothalamus in the warming acupuncture group were significantly higher than those in the normal saline group(P<0.01,P<0.05).The content of cortisol in the acupuncture group was significantly higher than that in the western medicine group(P<0.01).Conclusion Mongolian medicine warming acupuncture can improve a depressive disorder by regulating the level of central amino acid neurotransmitters,and alleviate anxiety symptoms in rats with the disease.
depressive disorderMongolian medicine warming acupuncturecentral amino acid neurotransmitterscortisol
万方数据
维普
