基于肠道菌群论健脾通腑法治疗桥本甲状腺炎
Treatment of Hashimoto thyroiditis by invigorating the spleen and dredging the fu viscera based on the theory of improving intestinal flora
李欣怡 1祁烁 2袁姣姣 1耿文倩 1吴艳珂 1司新颖 1马文源 1丁治国2
作者信息
- 1. 北京中医药大学东直门医院,北京 100700
- 2. 北京中医药大学孙思邈医院,陕西 铜川 727031
- 折叠
摘要
桥本甲状腺炎(HT)是临床常见自身免疫性疾病,改善肠道菌群是桥本甲状腺炎治疗的研究热点.脾虚是桥本甲状腺炎的核心病机,健脾通腑治疗桥本甲状腺炎疗效良好.脾脏与肠道菌群在生理病理方面关系密切,健脾通腑和改善肠道菌群作用机制具有一定相关性.健脾通腑类药物可促进胃肠道蠕动、改善免疫指标、恢复免疫细胞平衡等,重塑肠道微环境的免疫平衡,推测改善肠道菌群可能是健脾通腑法治疗桥本甲状腺炎的作用机制之一.
Abstract
Hashimoto thyroiditis(HT)is a common autoimmune disease in clinic,and improving intestinal flora is a research hotspot in its treatment.Spleen deficiency is the core pathogenesis of HT,hence strengthening the spleen and clearing the fu viscera is an effective method for treating the disease.The spleen and intestinal flora are closely related in their physiological and pathological aspects,and there is a certain correlation between strengthening the spleen and dredging the fu organs and improving the functions of intestinal flora.The drugs for invigorating the spleen and dredging the fu organs can reshape the immune balance of the intestinal microenvironment by promoting gastrointestinal peristalsis,improving immune indicators,restoring the immune cell balance,etc.It is speculated that improving intestinal flora may be one of the mechanisms of invigorating the spleen and dredging the fu viscera in treating Hashimoto thyroiditis.
关键词
桥本甲状腺炎/肠道菌群/健脾通腑法Key words
Hashimoto thyroiditis/intestinal flora/method for strengthening the spleen and dredging the fu viscera引用本文复制引用
基金项目
陕西省中医药局科研项目(2021-GJ-LC002)
陕西省秦创原"科学家+工程师"队伍建设项目(2022KXJ-019)
出版年
2024
国家科技期刊平台
NSTL
万方数据