Effect of modified Foshou Dingxuan decoction combined with nimagolin tablets in the treatment of patients with transient ischemic attack
Objective To observe the therapeutic effect of modified Foshou Dingxuan decoction combined with nimagolin tablets in patients with transient ischemic attack(TIA).Methods A prospective randomized controlled study was conducted on 91 patients with transient ischemic attack,who were divided into an observation group(45 cases)and a control group(46 cases)using a random number table method.During the study,one patient in the control group was excluded due to poor treatment compliance,and 45 cases were finally included in each of the two groups.The control group was given nimagolin tablets,while the observation group was given Foshou Dingxuan decoction combined with nimagolin tablets.Both groups were treated continuously for 4 weeks.The clinical efficacy of the two groups was compared after 4 weeks of treatment.The hemorheology indexes,oxidative stress indexes and lipid metabolism indexes were compared between the two groups before and after 4 weeks of treatment.The incidence of adverse reactions during the treatment period was compared between the two groups.Results The total effective rate of the observation group(95.56%,43/45)was higher than that of the control group(80.00%,36/45)(P<0.05).After 4 weeks of treatment,the plasma viscosity,whole blood high tangential viscosity,whole blood low tangential viscosity and hematocrit of both groups were lower than before treatment,and the observation group was lower than the control group(P<0.05).Malondialdehyde was lower than before treatment in both groups,while glutathione and superoxide dismutase were higher than before treatment,and malondialdehyde in the observation group was lower than the control group,while glutathione and superoxide dismutase were higher than the control group(P<0.05).Triglyceride,total cholesterol and low density lipoprotein cholesterol in the two groups were lower than before treatment,and the observation group was lower than the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of modified Foshou Dingxuan decoction and nimagolin tablets has a significant therapeutic effect in the treatment of transient ischemic attack,which can improve patients'hemorheology,alleviate oxidative stress reactions,regulate blood lipid metabolism,and have a good medication safety.
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