Effect analysis of Shugan Jianpi Huoxue Decoction in the treatment of Hashimoto's thyroiditis complicated with hypothyroidism
Objective To analyze the clinical effect of Shugan Jianpi Huoxue Decoction in the treatment of Hashimoto's thyroiditis(HT)complicated with hypothyroidism(CH).Methods A total of 100 patients with HT complicated with CH admitted to the hospital from February 2021 to January 2023 were divided into an experimental group and a control group by a random number table method,with 50 cases in each group.All of them received a basic treatment,with the control group treated with levothyroxine sodium tablets while the experimental group treated with levothyroxine sodium tablets combined with Shugan Jianpi Huoxue Decoction,both for 12 weeks.The TCM syndrome scores,thyroid function,clinical efficacy,inflammatory factors,depression and safety were compared between the two groups after treatment.Results After treatment,the main symptom scores,secondary symptom scores,total scores,peroxidase antibody(TPOAb),thyroglobulin antibody(TGAb),serum interferon gamma(IFN-y),interleukin-4(IL-4),General Anxiety Disorder-7(GAD-7)scores and Patient Health Questionnaire-9(PHQ-9)scores were all decreased in both groups(P＜0.05),and they were much lower in the experimental group(P＜0.05).After treatment,the serum levels of free thyroxine(FT4)and free thyrotriiodothyronine(FT3)were increased in both groups,and they were much higher in the experimental group(P＜0.05).The total effective rate of the experimental group(97.96％)was higher than that of the control group(83.33％)(P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion Shugan Jianpi Huoxue Decoction combined with levothyroxine sodium tablets is effective in improving the clinical symptoms of HT patients with hypothyroidism,which can reduce inflammatory reactions,improve the thyroid function,reduce the degree of depression,and have a good safety.
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