Clinical effect observation of Yiqi Qingli Huayu Recipe in the treatment of primary IgA nephropathy
Objective To explore the effects of Yiqi Qingli Huayu Recipe on the improvement of symptoms and the levels of inflammatory factors in the treatment of the syndrome of qi deficiency of spleen and kidney combined with dampness and stagnation in patients with primary IgA nephropathy.Methods A total of 264 patients with primary IgA nephropathy of the syndrome of qi deficiency of spleen and kidney combined with dampness and stagnation who were treated in our hospital from March 2020 to March 2021 were selected as the study subjects.According to the different treatment methods,they were divided into two groups:the control group and the treatment group,with 132 cases in each group.The control group was treated with losartan potassium,while the treatment group was treated with Yiqi Qingli Huayu Recipe on the basis of the control group.The safety and effectiveness of treatment,improvement of traditional Chinese medicine symptoms,changes in renal functions and inflammatory factors were analyzed.Results After treatment,the levels of urine red blood cell count,24-hour UTP,Scr,BUN,and UA were decreased in both groups,and the decrease was more significant in the treatment group(P＜0.05).After treatment,the scores of traditional Chinese medicine symptoms were decreased in both groups,and the scores were lower in the treatment group than those in the control group(P＜0.05).The effective rate of the treatment group(95.45％)was higher than that of the control group(68.18％)(P＜0.05).After treatment,the levels of hs-CRP,TNF-α,IL-2,IL-4,IL-5,and IL-6 were decreased in both groups,while the levels of IFN-γ,IL-10 were increased,and the range of changes was more significant in the treatment group(P＜0.05).Conclusion Yiqi Qingli Huayu Recipe can significantly improve the TCM symptoms,urinary red blood cell count and renal functions of patients with primary IgA nephropathy of the syndrome of qi deficiency of spleen and kidney combined with dampness and stagnation,reducing inflammatory reactions and having a reliability and safety.
Yiqi Qingli Huayu Recipesyndrome of qi deficiency of spleen and kidney combined with dampness and stagnationprimary IgA nephropathysymptom improvementinflammatory factors
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