摘要
目的 探讨应用汗法治疗对阴寒凝滞型不稳定型心绞痛患者的临床疗效.方法 选取78例2021年6月-2023年6月邢台医学高等专科学校第一附属医院收治的阴寒凝滞型不稳定型心绞痛患者按随机数字表法分为对照组(西医综合对症治疗)和治疗组(西医综合对症+寒痉汤治疗),各39例.2组均持续治疗4周.比较2组治疗4周后的心电图疗效、心绞痛疗效,治疗前、治疗4周后的中医症状积分、心功能水平、血清ET-1、NO、Cys-C、Hcy水平及血脂水平.结果 治疗组治疗4周后的心电图、心绞痛总有效率分别为97.44%、97.44%,高于对照组的79.49%、76.92%(P＜0.05).治疗4周后,2组中医症状各项评分、左室舒张末期内径(LVEDD)、血清ET-1、Cys-C、Hcy、血脂[三酰甘油(TG)、脂蛋白相关磷脂酶A2(Lp-PLA2)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)]水平低于治疗前,治疗组低于对照组(P＜0.05);2组心排血量(CO)、左心室射血分数(LVEF)、舒张早期/晚期最大血流速度(E/A)、血清NO、高密度脂蛋白胆固醇(HDL-C)水平高于治疗前,治疗组高于对照组(P＜0.05).结论 汗法可明显改善阴寒凝滞型不稳定型心绞痛患者临床症状,提高患者的心功能,稳定患者血脂水平,减轻血管病变情况,进而有利于提高心电图及心绞痛疗效.
Abstract
Objective To explore the clinical effect of diaphoresis in the treatment of unstable angina pectoris patients with the syndrome of yin cold congelation and stagnation.Methods From June 2021 to June 2023,78 unstable angina pectoris patients with the syndrome of yin cold congelation and stagnation admitted to the First Hospital of Xingtai City were randomly divided into two groups:a control group treated with comprehensive symptomatic western medicine and a treatment group treated with comprehensive symptomatic western medicine plus Hanjing decoction,with 39 cases in each group.Both groups were treated continuously for 4 weeks.The curative effects of ECG and angina pectoris were compared between the two groups after 4 weeks of treatment,and the scores of traditional Chinese medicine symptoms,the levels of cardiac function,serum ET-1,NO,Cys-C,Hcy and blood lipids were compared before and after treatment for 4 weeks.Results The total effective rates of ECG and angina pectoris were 97.44%and 97.44%respectively in the treatment group,higher than those in the control group(76.92%and 79.49%,P<0.05).After 4 weeks of treatment,the scores of traditional Chinese medicine symptoms,left ventricular end-diastolic diameter(LVEDD),levels of serum ET-1,Cys-C,Hcy,blood lipids[triglyceride(TG),lipoprotein-associated phospholipase A2(Lp-PLA2),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C)]were lower in both groups than those before treatment,and the treatment group was lower than the control group(P<0.05).The cardiac output(CO),left ventricular ejection fraction(LVEF),early/late diastolic maximum flow velocity(E/A),levels of serum NO and high-density lipoprotein cholesterol(HDL-C)were higher in both groups than those before treatment,and the treatment group was higher than the control group(P<0.05).Conclusion Diaphoresis can significantly improve the clinical symptoms in unstable angina pectoris patients with the syndrome of yin cold congelation and stagnation,improve cardiac function,stabilize blood lipid levels,alleviate vascular lesions,and thus improve the curative effects of ECG and angina pectoris.
基金项目
河北省2020年度中医药类科研计划项目(2020565)
邢台市科技计划项目(2023ZC116)
国家科技期刊平台
NSTL
万方数据