Effects of berberine on the expression of miR-132-3p and miR-137 and the insulin resistance in patients with diabetic encephalopathy
Objective To investigate the effects of berberine(BBR)on the expression of miR-132-3p and miR-137 and the insulin resistance in patients with diabetes encephalopathy(DE).Methods A total of 110 DE patients were selected as study subjects and randomly divided into a control group(55 cases)and an experimental group(55 cases).The control group was treated with metformin and a basic blood glucose control,while the experimental group was treated with berberine tablets on the basis of the control group.After 30 days of treatment,the clinical efficacy,blood glucose indexes,insulin function,homeostasis model assessment-insulin resistance(HOMA-IR)and Mini-mental State Examination(MMSE)scores and the expression levels of miR-132-3p and miR-137 in peripheral blood were compared between the two groups,and the correlation between the expression levels of miR-132-3p and miR-137 in peripheral blood and the HOMA-IR indexes was analyzed in the experimental group.Results The blood glucose indexes,HOMA-IR indexes and miR-137 level were lower in the experimental group than those in the control group,while the insulin function indexes,MMSE scores and miR-132-3p level were higher than those in the control group,with the differences all statistically significant(all P＜0.05).The HOMA-IR indexes of the experimental group were negatively correlated with the expression level of peripheral blood miR-132-3p while positively correlated with the expression level of peripheral blood miR-137,and the change of HOMA-IR indexes was significantly affected by the peripheral blood miR-132-3p and miR-137 expression,with a statistical significance(all P＜0.05).Conclusion Berberine can improve the clinical efficacy of conventional therapy in DE patients,or regulate the insulin resistance by affecting the expression levels of miR-132-3p and miR-137 to reduce blood glucose and protect their brain function.
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