Preliminary experimental study on the effect of Xiaozhongsan lotion on wound healing in rats
Objective To explore the effect of Xiaozhongsan lotion on wound healing in rats.Methods SD rats with a successful modeling were randomly divided into an experimental group(Xiaozhongsan lotion),a control group(compound Huangbai liquid)and a blank group(normal saline).The wound healing rate was recorded on the third,seventh,fourteenth and twenty-first days after modeling.The expression levels of angiopoietins(AngⅠ,AngⅡ)in wound tissue were detected on the 3rd,7th,and 14th days.The expression levels of inflammatory factors(IL-1β,IL-6,IL-10)in wound tissue were detected on the 7th day.Results On the third day after modeling,there was no significant difference in wound healing rate among the three groups(P>0.05).The wound healing rate of the experimental group was higher than that of the control group and the blank group on the 7th and 14th day(P<0.05).The wound healing rate of the experimental group was higher than that of the blank group on the 21st day(P<0.05),yet there was no significant difference between the experimental group and the control group(P>0.05).On the third day after modeling,there was no statistically significant difference in the expression levels of AngⅠ and AngⅡ between the experimental group and the control group(P>0.05),but their levels were significantly higher than those in the blank group(P<0.05).On the 7th day,there was a statistically significant difference in the expression levels of AngⅠ and AngⅡ between the experimental group and the control group(P<0.05),and their levels were also significantly higher than those of the blank group(P<0.05).The expression levels of AngⅠ and AngⅡ in the experimental group and control group on the 14th day were not significantly different(P>0.05),but were significantly higher than those in the blank group(P<0.05).On the 7th day after modeling,the expression levels of IL-1β and IL-6 in the experimental group were lower than those in the blank group and the control group(P<0.05),while IL-10 was higher than those in the other two groups(P<0.05).Conclusion Xiaozhongsan lotion can coordinate the balance of inflammatory factors,promote the expression of angiopoietin,and achieve the purpose of rapid wound healing.
SD ratsanimal experimentswound healinginflammatory factorsangiopoietinfumigation and washing of traditional Chinese medicine
万方数据
维普
