Effect of Honghua Ruyi pill in the treatment of chronic pelvic pain caused by pelvic inflammatory disease
Objective To study the effects of Honghua Ruyi pill on the pain degree,inflammatory response and uterine arterial hemodynamics in patients with chronic pelvic pain caused by pelvic inflammatory disease.Methods From September 2022 to September 2023,104 patients with chronic pelvic pain caused by pelvic inflammatory disease admitted to the gynecology outpatient at the Department of Integrated Chinese and Western Medicine of the First Affiliated Hospital of Zhengzhou University were enrolled in the treatment group(n=52)and the control group(n=52),using the random number table method.The treatment group was treated with Honghua Ruyi pill on the basis of conventional antibiotics treatment,while in the control group,Honghua Ruyi pill was replaced with a blank simulator.The efficacy of the two groups after 4 weeks of treatment,the changes in their TCM syndrome scores,pain degree,quality of life,inflammatory response,blood flow rate and hemodynamics before and after treatment were compared.Results After 4 weeks of treatment,the total effective rate of the treatment group(96.15％)was significantly higher than that of the control group(75.00％,P＜0.05).After 4 weeks of treatment,the scores of lower abdominal tingling,lumbosacral swelling pain,abnormal vaginal discharges,menstrual visual analogue scale(VAS)scores,non-menstrual VAS scores,leukocyte esterase positive rate in vaginal discharges,whole blood erythrocyte sedimentation rate(ESR),serum interleukin-6(IL-6)level and uterine artery resistance index(RI)were all decreased in both groups compared with before treatment,and they were much lower in the treatment group(P＜0.05).Compared with before treatment,after 4 weeks of treatment,the scores of the World Health Organization Quality of Life(WHOQOL-BREF),levels of uterine perfusion index(PI)and peak systolic velocity(PSV)were all increased in the two groups,and they were much higher in the treatment group(P＜0.05).Conclusion Honghua Ruyi pill can achieve a good curative effect in the treatment of patients with chronic pelvic pain caused by pelvic inflammatory disease,which can improve their TCM syndrome scores,relieve pain degree,reduce inflammatory response,regulate blood flow velocity and hemodynamics,and improve their quality of life.
万方数据
维普
