Clinical observation on the efficacy and safety of Suyin Jiedu Granules in the treatment of third-to fifth-stage chronic kidney disease
Objective To investigate the efficacy and safety of Suyin Jiedu Granules in the treatment of third-to fifth-stage chronic kidney disease.Methods A total of 200 patients with third-to fifth-stage chronic kidney disease were randomly divided into an observation group and a control group.Both groups received a routine basic treatment,while the observation group was treated with Suyin Jiedu Granules on that basis.The improvement of TCM scores of the syndrome of turbid toxin due to kidney deficiency,the 24-hour urine protein quantification,the urine microalbumin,the renal function indicators[serum creatinine(Scr),estimated glomerular filtration rate(eGFR),blood urea nitrogen(BUN),albumin(ALB)],the blood routine and blood lipid indicators[red blood cell count(RBC),hemoglobin(Hb),triglycerides(TG),total cholesterol(TC)]were observed before and after treatment in the two groups,and the total effective rates and adverse reactions of the two groups were calculated.Results After treatment,the scores for symptoms such as fatigue,lower back pain,edema,nausea and vomiting,frequent nocturia,the 24-hour urinary protein quantification,the levels of urinary microalbumin,the levels of Scr and BUN,and the levels of blood TG and TC were significant lower in the observation group than those in the control group(P<0.05),while the indicators of eGFR and ALB,the indicators of blood RBC and Hb,and the total effective rate were all higher in the observation group than those in the control group(P<0.05).There was no significant difference in adverse reactions between the two groups.Conclusion The application of Suyin Jiedu Granules can reduce the levels of blood and urine protein in patients with third-to fifth-stage chronic kidney disease,improve renal function,and regulate blood routine and lipid metabolism,which help alleviate clinical symptoms and achieve a significant therapeutic effect.