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南征教授应用蛋白1号方加味治疗消渴肾病

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目的 观察南征教授蛋白1号方加味治疗消渴肾病的临床效果.方法 选取长春中医药大学附属医院就诊的70例消渴肾病患者,随机分为观察组和对照组,各35例.对照组在常规治疗基础上予复方α-酮酸片治疗,观察组在常规治疗基础上给予蛋白1号方加味治疗.比较2组临床疗效、24 h尿蛋白定量、空腹血糖(fasting blood glucose,FBG)、餐后2 h血糖(postprandial blood glucose,PBG)、糖化血红蛋白(glycosylated hemoglobin,HbA1c)及血尿酸(serum uric acid,UA)变化情况.结果 观察组总有效率(100%)显著高于对照组48.57%(P<0.05);2组治疗后24 h尿蛋白定量、FBG、PBG、HbA1C、UA均优于治疗前,且观察组优于对照组(P<0.05).结论 蛋白1号方加味可缓解消渴肾病患者临床症状,改善临床指标,提高患者生存质量,为中医药治疗消渴肾病提供新的思路.
Clinical effect of the modified Protein No.1 prescription in the treatment of diabetic nephropathy by Professor Nan Zheng
Objective To explore the clinical effect of the modified Protein No.1 prescription created by Professor Nan Zheng in the treatment of diabetic nephropathy.Methods A total of 70 patients with diabetic nephropathy who visited the Affiliated Hospital of Changchun University of Chinese Medicine were randomly divided into an observation group and a control group,with 35 patients in each group.The control group was treated with compound α-keto acid tablets on the basis of a routine treatment,while the observation group was treated with the modified Protein No.1 prescription on the basis of a routine treatment.The clinical efficacy,the levels of 24-hour urinary protein quantification,fasting blood glucose(FBG),2-hour postprandial blood glucose(PBG),glycosylated hemoglobin(HbA1c)and serum uric acid(UA)were observed in the two groups.Results The total effective rate of the observation group was 100%,significantly higher than that of the control group(48.57%,P<0.05).After treatment,the levels of 24-hour urinary protein,FBG,PBG,HbA1C,and UA were better in both groups than before treatment,and the observation group was better than the control group(P<0.05).Conclusion The Protein No.1 prescription is effective in the treatment of diabetic nephropathy,which can alleviate clinical symptoms,improve clinical indicators,and enhance the quality of life of patients,providing a new idea for the treatment of diabetic nephropathy with traditional Chinese medicine.

diabetic nephropathytheory of toxin damaging kidney collateralsProtein No.1 prescriptionNan Zheng

孟琦、初昀杭、南征、朴春丽、杨明

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长春中医药大学,长春 130117

长春中医药大学附属医院内分泌代谢病科,长春 130021

广州中医药大学附属深圳医院<福田>,广州 深圳 518000

消渴肾病 毒损肾络学说 蛋白1号方 南征

2024

吉林中医药
长春中医药大学

吉林中医药

CSTPCD
影响因子:0.843
ISSN:1003-5699
年,卷(期):2024.44(12)