Tenofovir Alafenamide Fumarate(TAF)is novel nucleoside reverse transcriptase inhib-itor(NRTI)mainly used for the treatment of chronic hepatitis B.Impurity research is the key to drug quality research,which directly affects the safety and effectiveness of drugs.In order to control the quality standard of the tenofovir alafenamide fumarate(TAF),five related substances were designed and synthesized according to the current synthesis process.
关键词
替诺福韦艾拉酚胺/抗乙肝病毒/相关杂质/合成
Key words
tenofovir alafenamide/anti-hepatitis B virus/related impurities/synthesis
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