Synthesis of Disubstituted Pyrrole Derivatives and Promotion of Strong Alkaline Reagent DBU
A strong basic reagent 1,8-diazadicycloundecane 7-ene was used to promote the synthesis of dissubstituted derivatives and improve the preparation efficiency of dissubstituted deriva-tives.The experimental results show that the yield of 2,4-dissubstituted pyrrole compound without u-sing strong basic reagent is 20％,and the yield of 2,4-dissubstituted pyrrole compound increases from 20％ to 55％ after using strong basic reagent,and increases with the increase of the use of DBU reagent, and the final yield is stable at 85％.In summary,the proposed method of promoting the synthesis of dissubstituted pyrrole derivatives with strong alkaline reagents is simple,efficient and controllable, which lays a foundation for further exploration of its application in medicine and materials science.
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