Comparison of the Two Methods for Determining the Active Ingredients in Compound Sulfamethoxazole Tablets
Comparison of sulfamethoxazole(SMZ)and trimethoprim(TMP)in compound sulfa-methoxazole tablets by double wavelength spectrophotometry using standard curve and single point methods.The results showed a good linear relationship between the concentration of the standard curve method and the absorption difference,and the average recovery and RSD of the two tested components were SMZ 99.59%and 0.83%,TMP 99.30%and 0.15%.The recovery of SMZ was 93.58%and 99.08%for TMP.Both methods showed better recovery rate,higher accuracy of standard curve method and easier operation of single point method,which can be used as a reference method for quality control of this tablet.