Objective:To explore the clinical efficacy of extraperitoneal transvesical single-port robot-assisted radical prostatectomy.Methods:A retrospective analysis was performed on 10 patients who underwent extraperitoneal transvesical single-port robot-assisted radical prostatectomy(ETvSP-RARP)in Xinhua Hospital Affiliated to Shanghai Jiao Tong University from September 2021 to June 2022.They were followed up at 2 weeks,3 months and 6 months after catheter removal to evaluate their recovery of tumor control,urinary continence and sexual function.Results:All surgeries were successfully completed without conversion to open surgery.The average operative time was 135(110-160)min,and the average intraoperative blood loss was 115(80-150)mL.Postoperative pathology indicated that 1 patient had positive surgical margin,who received postoperative endocrinotherapy and radiotherapy.T-PSA level in other patients decreased to less than 0.02 ng/mL 6 weeks after surgery.The urinary control rates at 6 weeks and 3 months after surgery were 6(60%)and 10(100%),respectively.However,penises were failure to erect after surgery.Conclusion:ETvSP-RARP can better preserve the structure of the prevesical space with the lower degree of stress incontinence,and the early recovery of urinary continence after surgery is good.