The work aims to propose an engineering method with practical significance to predict the response of plate shell structure under vibro-acoustic coupling.Based on the response curves of noise test,vibration test and vibro-acoustic test,the re-sponse coupling law of plate shell structure under simultaneous excitation of noise and vibration was analyzed,and the response distribution of plate shell structure under vibro-acoustic test was predicted according to the response extremum envelope method of noise test and vibration test.The response curve of vibro-acoustic test was approximately the maximum envelope line of the noise test and vibration test.The surface excitation of noise and the basic excitation of random vibration mainly impacted the structural response in different frequency ranges.Response curves of noise test and vibration test intersected at the given fre-quency point.The response of vibro-acoustic test below the crossing frequency was highly consistent with the result of vibration test,while the response above the crossing frequency was mainly similar to the noise test.Based on these results,the extremum envelope method can be used to predict the response of plate shell structure under vibro-acoustic test by the response data of noise test and vibration test in engineering practices.In addition,the response superposition method is more suitable because it is difficult to obtain the crossing frequency in advance.