Blockchain,with its disruptive innovative technology,is continuously changing the opera-tional rules and application scenarios of various industries such as digital finance,digital government,Internet of Things,and intelligent manufacturing.It is an indispensable key technology for building a new trust and value system in the future society.However,due to the defects of its own technology and the complexity and diversity of application scenarios,the security issues of blockchain are becoming in-creasingly serious.Security has become a major bottleneck restricting the future development of block-chain,and the road to blockchain regulation is arduous.This paper introduces the background know-ledge,basic concepts,and architecture of blockchain.Starting from the architecture of blockchain,it analyzes the security issues and prevention strategies of blockchain from seven aspects:data layer,net-work layer,consensus layer,incentive layer,contract layer,application layer,and cross-chain.Based on this,it discusses the safety supervision of blockchain from the current situation and difficulties of policy supervision,the establishment of technical supervision standards,innovative methods,and deve-lopment trends.