To meet the growing performance challenge of international thermonuclear experimental reactor (ITER) program' s global network, a WAN optimization scheme is proposed, combining high-speed protocol and improved transport mechanisms. Based on deep research for the Xpress transport protocol (XTP), made use of feature-rich interface provided by XTP, adjust the burst/rate model to avoid congestion effectively, marked sequence numbers of packet to improve go-back-n retransmission algo-rithm, also employed protocol spoofing to reduce the latency, some relevant protocol fields are analyzed to implement accurate QoS policy, and the characteristics of XTP are used for a flexible network improvement. The experimental results show that the solution can significantly improve the performance of China-France global network for ITER.