With the rapid development of cross-border e-commerce,the cultivation mode of cross-border e-commerce operation talents is urgent.Effectively promoting the construction of Cross-border E-commerce Operation course is of great significance for training cross-border e-commerce operation talents who meet the needs of the development of the times.At present,there are many problems in the implementation of Cross-border E-commerce Operation course in higher vocational colleges,and it is urgent to adapt to the needs of the times and make correspoding adjustments and changes.This paper takes Cross-border E-Commerce Operation course as the research object,discusses the deficiencies in the teaching process of this course in higher vocational colleges,and puts forward the exploration of five paths:reconstructing the teaching content,adopting the"five segments and three sexes"teaching mode,improving the practical ability through multi-channels,making full use of information technology,and implementing value-added evaluation.This study can provide some comprehensive,systematic and scientific references and ideas for the curriculum reform of Cross-border E-commerce Operation in higher vocational colleges.