Determination of 39 Pharmaceuticals and Personal Care Products in Drinking Water by Solid Phase Extraction-High Performance Liquid Chromatography Tandem Mass Spectrometry
An analytical method for the simultaneous determination of 39 pharmaceuticals and personal care products(PPCPs)in drinking water using solid-phase extraction,high-performance liquid chromatography,and tandem mass spectrometry was established.After being extracted by HLB solid phase extraction column,the sample was concentrated and directly sent to the high performance liquid chromatography-mass spectrometer for analysis.The Agilent PFP column(2.1 mm×100 mm,2.7 μm)was used for separation.Methanol-0.1％formic acid aqueous solution was used as the mobile phase for gradient elution.The electrospray AJS ion source positive ion(ESI)mode was used for scanning,and the multi reaction monitoring mode(MRM)was used for detection.The results showed that 39 PPCPs exhibit good linear relationships within different linear ranges of 0.05～100 μg/L(r=0.995 4～0.999 9),and the detection limit of the method was from 0.029 to 1.300 ng/L.The recovery rates of 39 PPCPs for actual samples of drinking water at low,medium,and high spiking levels were 63.0％～123.0％,70.1％～126.0％,and 78.7％～122.0％,respectively,with relative standard deviations of 1.4％～19.0％,0.7％～9.3％,and 0.6％～9.8％.This detection method achieves the simultaneous determination of 39 PPCPs using a conventional high-performance liquid chromatography mass spectrometer,and can meet the precision and accuracy requirements of national standard.It has the advantages of simple operation and high sensitivity,and is suitable for the detection of PPCPs in drinking water.
solid phase extractionliquid chromatography-mass spectrometrydrinking waterpharmaceuticalspersonal care product
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