Objective To investigate the risk factors of anastomotic fistula after esophageal canc-er surgery.Methods The clinical data of 107 patients with esophageal cancer surgery were retro-spectively analyzed,among whom 21 patients with anastomotic fistula after surgery were included in observation group,and 86 patients without anastomotic fistula after surgery were included in control group.The risk factors of anastomotic fistula after esophageal cancer surgery were identified by univa-riate analysis and multivariate Logistic regression analysis.Results Univariate analysis showed that age,hypoproteinemia,history of diabetes,preoperative neoadjuvant therapy,and anastomotic site were associated with anastomotic fistula after esophageal cancer surgery(P＜0.05);multivariate Lo-gistic regression analysis showed that preoperative neoadjuvant therapy was an independent risk factor for postoperative anastomotic fistula in patients with esophageal cancer(OR=5.392;95％CI,1.335 to 30.382;P=0.020).Conclusion Preoperative neoadjuvant therapy is an independent risk factor for postoperative anastomotic fistula in patients with esophageal cancer.For patients with preoperative comorbid diseases,especially diabetes and hypoproteinemia,adequate preoperative preparation should be made.
关键词
食管癌手术/吻合口瘘/新辅助治疗/低白蛋白血症/糖尿病/危险因素
Key words
esophageal cancer surgery/anastomotic fistula/neoadjuvant therapy/hypoalbu-minemia/diabetes/risk factors
维普
万方数据