首页|幽门螺杆菌相关慢性胃炎的胃微生态特征分析

幽门螺杆菌相关慢性胃炎的胃微生态特征分析

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目的 探讨幽门螺杆菌(H。pylori)相关慢性非萎缩性胃炎和慢性萎缩性胃炎的胃菌群特征及差异。方法 采用前瞻性研究设计，将24例H。pylori感染的慢性胃炎患者分为慢性非萎缩性胃炎组(n=18)和慢性萎缩性胃炎组(n=6)。测定2组的胃黏膜菌群特征，并进行Alpha和Beta多样性分析及物种相关性分析。结果 2组胃菌群均主要包括变形菌门、拟杆菌门、厚壁菌门、放线菌门和梭杆菌门。2组胃菌群的物种多样性和丰度差异具有统计学意义(ANOSIM分析，P=0。046)。慢性萎缩性胃炎组的梭杆菌属(P=0。023)、纤毛菌属(P=0。047)、普雷沃菌属(P=0。016)、月形单胞菌属(P=0。042)和密螺旋体属(P=0。006)显著富集，H。pylori呈下降趋势(P=0。218)。胃黏膜菌群的部分菌属与H。pylori呈负相关性，且慢性萎缩性胃炎的胃黏膜菌群中与H。pylori负相关的菌属种类明显减少。结论 慢性萎缩性胃炎的胃黏膜中梭杆菌属、纤毛菌属、普雷沃菌属、月形单胞菌属和密螺旋体属显著富集，与慢性胃炎进展相关。
Characteristics of gastric microbiota in Helicobacter pylori associated chronic gastritis
Objective To investigate the characteristics and differences of gastric flora in chronic non-atrophic gastritis and chronic atrophic gastritis associated with Helicobacter pylori(H.pylori).Methods A prospective study was adopted,and 24 patients with chronic gastritis caused by H.pylori infection were divided into chronic non-atrophic gastritis group(n=18)and chronic atrophic gastritis group(n=6).Characteristics of gastric mucosal flora in both groups were determined,and Alpha and Beta diversity analyses and species correlation analysis were performed.Results The gastric flora in both groups were mainly consisted of Proteobacteria,Bacteroidetes,Firmicutes,Actinobacteria,and Fusobacteria.Significant differences in species diversity and abundance were observed between the two groups(ANOSIM analysis,P=0.046).Fusobacterium(P=0.023),Leptotrichia(P=0.047),Prevotella(P=0.016),Sphingomonas(P=0.042),and Treponema(P=0.006)were significantly enriched in the chronic atrophic gastritis group,and H.pylori showed a decreasing trend(P=0.218).Some species of gastric mucosal flora showed negative correlations with H.pylori,and the number of species negatively associated with H.pylori in the gastric mucosal flora of chronic atrophic gastritis was significantly reduced.Conclusion In the gastric mucosa of chronic atrophic gastritis,the Fusobacterium,Leptotrichia,Prevotella,Sphingomonas,and Treponema are significantly enriched and associated with the progression of chronic gastritis.

Helicobacter pylorigastric floraHelicobacter pylori associated chronic gastritischronic non-atrophic gastritischronic atrophic gastritisdifferential analysis

牛占岳、石岩岩、李司柱、薛艳

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北京大学第三医院消化科,北京,100191

北京大学第三医院临床流行病学研究中心,北京,100191

幽门螺杆菌 胃菌群 幽门螺杆菌相关慢性胃炎 慢性非萎缩性胃炎 慢性萎缩性胃炎 差异分析

中国医药卫生事业发展基金会资助课题北京大学第三医院临床重点项目北京大学第三医院临床重点项目

LM2023782BYSY2017026BYSYZD2021034

2024

10.7619/jcmp.20233613

实用临床医药杂志
扬州大学,中国高校科技期刊研究会

实用临床医药杂志

CSTPCD
影响因子：1.543
ISSN：1672-2353
年,卷(期)：2024.28(1)
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