Influencing factors of re-occlusion after intravenous thrombolysis of alteplase in patients with cerebral infarction and therapeutic effect of tirofiban
Objective To investigate the influence factors of re-occlusion after intravenous thrombol-ysis of alteplase in patients with cerebral infarction and the therapeutic effect of tirofiban.Methods A total of 100 patients with cerebral infarction were selected as the study objects.The patients were di-vided into occlusion group(n=42)and non-occlusion group(n=58)according to whether re-occlu-sion after intravenous thrombolysis with alteplase.The occlusion group was given tirofiban treatment.General data were compared between two groups.Logistic regression model was used to analyze the in-fluencing factors of re-occlusion after alteplase intravenous thrombolysis in patients with cerebral infarc-tion.The total effective rate,recombinant human tissue plasminogen activator(rPA),plasminogen acti-vator inhibitor-1(PAI-1)levels and the score of National Institutes of Health Stroke Scale(NIHSS)and Simple Mental State Scale(MMSE)in the occlusion group were observed.Results There were statistically significant differences in type 2 diabetes mellitus,blood glucose,systolic blood pressure,NIHSS score and onset-thrombolysis time between the two groups(P＜0.05).Logistic regression a-nalysis showed that type 2 diabetes mellitus,blood glucose,systolic blood pressure,NIHSS score,and onset-thrombolytic time were the influential factors of re-occlusion after intravenous thrombolytic alte-plase in cerebral infarction patients(P＜0.05).The total effective rate was 88.10％(37/42)in 42 pa-tients with re-occlusion after thrombolytic therapy.After 3 and 7 days of treatment,rPA was significantly higher than before treatment,PAI-1 was significantly lower than before treatment(P＜0.05);after 1 week,2 and 4 weeks of treatment,MMSE score was significantly higher than before treatment,NIHSS score was significantly lower than before treatment(P＜0.05).Conclusion Type 2 diabe-tes mellitus,blood glucose,systolic blood pressure,NIHSS score,and time of onset and thrombolyt-ic therapy may affect the re-occlusion of patients with cerebral infarction after alteplase intravenous thrombolytic therapy.The effect of tirofiban after re-occlusion is better,which is beneficial to im-prove the neurological function,rPA and PAI-1 levels of patients.
万方数据
维普
