首页|1例抗IgLON家族蛋白5抗体相关脑病的病例报告

1例抗IgLON家族蛋白5抗体相关脑病的病例报告

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本研究报道1例50岁女性患者,表现为认知障碍和睡眠障碍,伴自主神经功能障碍、癫痫发作,脑脊液抗IgLON家族蛋白5(IgLON5)抗体阴性,血清抗IgLON5抗体阳性,基因检测人类白细胞抗原(HLA)阴性,诊断为抗IgLON5抗体相关脑病.患者入院后予甲泼尼龙冲击联合静脉注射免疫球蛋白免疫治疗、多奈哌齐改善认知、丙戊酸钠和奥卡西平抗癫痫发作,症状明显改善.
A case report with anti-IgLON family member 5 antibody-related encephalopathy
This study reported a 50-year-old female patient who was diagnosed with anti-IgLON family member 5(anti-IgLON5)antibody-related encephalopathy,presented with cognitive and sleep disorders,autonomic dysfunction and seizures,positive serum IgLON5 antibody but negative cerebro-spinal fluid IgLON5 antibody,negative human leukocyte antigen(HLA)by genetic testing,and was diagnosed as anti-IgLON5 antibody-related encephalopathy.After hospital admission,the patient was given intravenous methylprednisolone combined with immunoglobulin immunotherapy,donepezil for improvement of cognition,sodium valproate and oxcarbazepine for prevention and treatment of epilep-tic seizures,and finally her symptoms improved significantly.

autoimmune encephalitisanti-IgLON family member 5 antibody-related encepha-lopathycognitive disordersleep disorderepilepsyimmunotherapy

彭勇、马灿灿、朱琳、陈蓓蕾、殷梦媚、吴健、俞龙、侯文哲

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扬州大学医学院,江苏扬州,225009

扬州大学临床医学院/扬州大学附属苏北人民医院神经内科,江苏扬州,225001

自身免疫性脑炎 抗IgLON家族蛋白5抗体相关脑病 认知障碍 睡眠障碍 癫痫 免疫治疗

2022年度省级学科带头人B类江苏省"333工程"培养对象扬州市十三五科教强卫重点人才

DTRB202210RC3330527RCC201838

2024

10.7619/jcmp.20233402

实用临床医药杂志
扬州大学,中国高校科技期刊研究会

实用临床医药杂志

CSTPCD
影响因子：1.543
ISSN：1672-2353
年,卷(期)：2024.28(2)
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