This study reported a 50-year-old female patient who was diagnosed with anti-IgLON family member 5(anti-IgLON5)antibody-related encephalopathy,presented with cognitive and sleep disorders,autonomic dysfunction and seizures,positive serum IgLON5 antibody but negative cerebro-spinal fluid IgLON5 antibody,negative human leukocyte antigen(HLA)by genetic testing,and was diagnosed as anti-IgLON5 antibody-related encephalopathy.After hospital admission,the patient was given intravenous methylprednisolone combined with immunoglobulin immunotherapy,donepezil for improvement of cognition,sodium valproate and oxcarbazepine for prevention and treatment of epilep-tic seizures,and finally her symptoms improved significantly.
关键词
自身免疫性脑炎/抗IgLON家族蛋白5抗体相关脑病/认知障碍/睡眠障碍/癫痫/免疫治疗
Key words
autoimmune encephalitis/anti-IgLON family member 5 antibody-related encepha-lopathy/cognitive disorder/sleep disorder/epilepsy/immunotherapy
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