Polymyxins are the last resort for the treatment of multidrug-resistant Gram-negative bacterial infections,but their neurotoxicity limits their clinical application.This paper discussed the molecular structure of polymyxins as well as the clinical manifestations,toxicity mechanisms,and pre-vention measures of their neurotoxicity,and it also pointed out the shortcomings of existing researches on neurotoxicity reports,and attempted to correlate the daily dose of polymyxins with neurotoxicity manifestations based on existing literatures,providing a reference for the rational use of polymyxins and the prevention of neurotoxicity in clinical practice.
关键词
黏菌素/多黏菌素B/分子结构/神经毒性/机制/保护剂
Key words
colimycin/polymyxin B/structure of molecules/neurotoxicity/mechanism/pro-tective agents
维普
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