Diagnostic value of combining carotid intima-media thickness with serum galectin-3 and pentraxin 3 in patients with psoriasis complicated with cardiovascular disease
Objective To investigate the diagnostic value of combining carotid intima-media thickness(cIMT)with serum Galectin-3(Gal-3)and Pentraxin 3(PTX3)in patients with psoriasis complicated with cardiovascular disease(C VD).Methods Thirty-eight patients with psoriasis com-plicated with CVD were included in CVD group,51 patients with psoriasis alone were included in pso-riasis group,and 60 healthy subjects were selected as control group.Clinical data were collected from each group.The cIMT was measured using carotid ultrasound,and serum Gal-3,PTX3,and inflamma-tory markers[high sensitivity C-reactive protein(hs-CRP),procalcitonin(PCT),tumor necrosis fac-tor-α(TNF-α)]were detected using enzyme-linked immunosorbent assay.Multivariate Logistic regression analysis was used to identify the influencing factors of CVD in patients with psoriasis.The receiver operating characteristic(ROC)curve was plotted to evaluate the diagnostic value of serum Gal-3,PTX3,and cIMT for CVD.Results The cIMT was greater in the CVD group and the psoriasis group than in the control group,and the CVD group was greater than the psoriasis group(P＜0.05).The serum levels of Gal-3,PTX3,hs-CRP,PCT,and TNF-α were higher in the CVD group and the psoriasis group than in the control group,and their levels were higher in the CVD group than in the psoriasis group(P＜0.05).The psoriasis area and severity index(PASI)score was higher in the CVD group than in the psoriasis group(P＜0.05).Pearsons correlation analysis showed that cIMT,Gal-3,and PTX3 were separately positively correlated with hs-CRP,PCT,and TNF-α(P＜0.05).Multivariate Logistic regression analysis showed that PASI score,cIMT,Gal-3,PTX3,hs-CRP,and TNF-α were independent influencing factors for CVD in patients with psoriasis(OR=1.250,1.451,1.432,1.365,1.413,1.465;P＜0.05).The diagnostic model based on cIMT combined with serum Gal-3 and PTX3 had higher diagnostic value for CVD in patients with psoriasis than single diagnosis.The area under the curve was 0.922,with sensitivity and specificity of 0.91 and 0.85,respectively.Conclusion The cIMT,serum Gal-3,and serum PTX3 are inde-pendent influencing factors for CVD in patients with psoriasis.The combination of the three indica-tors has higher diagnostic value for CVD in patients with psoriasis.
万方数据
维普
