Relationships of ultrasound vascular index quantification and elastic modulus with biological characteristics of breast cancer and its clinical significance
Objective To explore the relationships of ultrasound vascular index quantification and elastic modulus with biological characteristics of breast cancer and its clinical significance.Meth-ods A total of 103 patients with breast cancer who received neoadjuvant chemotherapy(NAC)were selected as study subjects.The relationships of the quantification of vascular index(Ⅵ)and maxi-mum elastic modulus(Emax)of shear wave elastography(SWE)with the biological characteristics of breast cancer before NAC were analyzed.According to the pathological response of NAC,the patients were divided into significant response group and non-significant response group.The change rates ofⅥ and Emax at the end of different cycles of NAC were compared between the two groups.Receiver operating characteristic(ROC)curve was used to analyze the change rates of Ⅵ and Emax at the end of different cycles to predict the pathological response of NAC in breast cancer.Results Before NAC,Ⅵ and Emax were related to the degree of differentiation,pathological stage and HER-2 expres-sion in breast cancer tissues(P＜0.05).The significant response group had higher change rates ofⅥ and Emax at the end of 1,2,and 4 week of NAC compared to the non-significant response group(P＜0.01).At the end of the second cycle,AUG of change rates of Ⅵ combined with Emax predicted the pathological response of NAC in breast cancer was 0.918,with the sensitivity of 0.874,and specificity of 0.905,which were higher than 0.832 of AUC,0.78 of sensitivity,and 0.827 of specificity at the end of 1 week of NAC,and were higher than 0.853 of AUC,0.827 of sensitivity,and 0.849 of spe-cificity at the end of the fourth week.Conclusion Ⅵ and Emax are correlated with the degree of dif-ferentiation,pathological stage and HER-2 expression in breast cancer.At the end of the second cy-cle of chemotherapy,the change rates of the Ⅵ combined with Emax have the best efficacy in predic-ting the pathological reaction of NAC in breast cancer.
breast cancerquantitative vascular indexelastic modulusbiological charac-teristicsclinical significance
万方数据
维普
