Predictive value of serum microRNA-506 and microRNA-934 levels in postoperative survival outcome of patients with pancreatic cancer
Objective To investigate the predictive value of serum microRNA-506(miR-506)and microRNA-934(miR-934)expression levels in postoperative survival outcomes of patients with pancreatic cancer.Methods A total of 115 patients with pancreatic cancer who received surgical treatment were selected as the study group,and were divided into survival group(n=18)and death group(n=97)according to the follow-up results.Fifty patients with benign pancreatic lesions in the same period were selected as control group;fifty healthy volunteers were selected as the healthy group.Quantitative real-time polymerase chain reaction(qRT-PCR)was used to detect the relative expression levels of miR-506 and miR-934 in serum of each group.Multivariate Logistic regression a-nalysis was used to analyze the influencing factors of postoperative survival outcomes in patients with pancreatic cancer.The predictive value of serum miR-506 and miR-934 in postoperative survival out-come of pancreatic cancer patients was analyzed by receiver operating characteristic(ROC)curve.Results The expression level of serum miR-506 in the study group was significantly lower than that in the control group(P＜0.05).The expression level of serum miR-934 in the study group was sig-nificantly higher than that in the control group and healthy group(P＜0.05).The expression level of serum miR-506 in the survival group was significantly higher than that in the death group,and the ex-pression level of serum miR-934 was significantly lower than that in the death group(P＜0.05).The miR-506,miR-934,TNM stage and lymph node metastasis were independent factors influencing post-operative survival of pancreatic cancer patients(P＜0.05).Conclusion The expression of miR-506 is low in the serum of patients who died after pancreatic cancer surgery,and the expression of miR-934 is high in the serum of patients who died after pancreatic cancer surgery.The value of miR-506 and miR-934 in predicting postoperative survival outcome of pancreatic cancer patients is high.
pancreatic cancermicroRNA-506microRNA-934survival outcomepredic-tive value
万方数据
维普
