首页|CT联合分泌型卷曲受体蛋白4及可溶性生长刺激表达基因2蛋白对恶性胆道梗阻患者术后并发胰腺炎的诊断价值

CT联合分泌型卷曲受体蛋白4及可溶性生长刺激表达基因2蛋白对恶性胆道梗阻患者术后并发胰腺炎的诊断价值

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目的 探讨计算机断层扫描(CT)联合血清分泌型卷曲受体蛋白4(SFRP4)及可溶性生长刺激表达基因2蛋白(sST2)对恶性胆道梗阻(MBO)患者胆管支架置入术后并发胰腺炎的诊断价值。方法 选取行胆管支架置入术的243例MBO患者为研究对象，根据术后并发胰腺炎情况分为胰腺炎组105例和无胰腺炎组138例。采用酶联免疫法检测SFRP4、sST2水平，采用受试者工作特征(ROC)曲线和四表格法分析SFRP4、sST2单独及联合CT诊断术后并发胰腺炎的临床价值。结果 胰腺炎组血清SFRP4、sST2水平高于无胰腺炎组，差异有统计学意义(P＜0。05);血清SFRP4、sST2水平诊断术后并发胰腺炎的曲线下面积(AUC)为0。694、0。667。CT诊断术后并发胰腺炎的敏感度为76。19％，特异度为60。87％;CT联合血清SFRP4、sST2水平诊断术后并发胰腺炎的敏感度为98。10％、准确度为76。54％;三者联合诊断的敏感度和准确度高于CT、SFRP4、sST2单独诊断，差异有统计学意义(P＜0。05)。结论 胆管支架置入术后并发胰腺炎的MBO患者血清SFRP4、sST2水平较高，CT联合血清SFRP4、sST2水平对术后并发胰腺炎具有较高的诊断价值。
Diagnostic value of CT combined with serum secreted frizzled-related protein 4 and soluble suppression of tumorigenicity 2 for postoperative complicated pancreatitis in patients with malignant biliary obstruction
Objective To investigate the diagnostic value of computer tomography(CT)com-bined with serum secreted frizzled-related protein 4(SFRP4)and soluble suppression of tumorigenici-ty 2(sST2)for pancreatitis after biliary duct stent implantation in patients with malignant biliary ob-struction(MBO).Methods A total of 243 MBO patients with biliary duct stent implantation were selected as research objects,and they were divided into pancreatitis group with 105 cases and no pan-creatitis group with 138 cases according to condition of postoperative complicated pancreatitis.En-zyme-linked immunosorbent assay was used to detect serum levels of SFRP4 and sST2,and the re-ceiver operating characteristic(ROC)curve and the four table method were used to analyze the diag-nostic values of serum SFRP4 or sST2 alone and their combination with CT for postoperative compli-cated pancreatitis.Results The serum levels of SFRP4 and sST2 in the pancreatitis group were sig-nificantly higher than those in the no pancreatitis group(P＜0.05);the values of area under the curve(AUC)of serum SFRP4 and sST2 levels for diagnosis of postoperative complicated pancreatitis were 0.694 and 0.667,respectively.The sensitivity and specificity of CT for diagnosis of postoperative complicated pancreatitis were 76.19％and 60.87％,respectively;the sensitivity and accuracy of CT combined with serum SFRP4 and sST2 levels in diagnosing postoperative complicated pancreatitis were 98.10％and 76.54％,respectively;the sensitivity and accuracy of the combination of the three indexes for diagnosis were significantly higher than those of CT,SFRP4 or sST2 alone(P＜0.05).Conclusion MBO patients with pancreatitis after biliary duct stent implantation have high-er serum levels of SFRP4 and sST2,and CT combined with serum levels of SFRP4 and sST2 has high diagnostic value for postoperative complicated pancreatitis.

computer tomographysecreted frizzled-related protein 4soluble suppression of tumorigenicity 2malignant biliary obstructionbiliary duct stent implantationpancreatitis

柳群力、朱鸷翔

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河南大学第一附属医院医学影像科,河南开封,475000

计算机断层扫描 分泌型卷曲受体蛋白4 可溶性生长刺激表达基因2蛋白 恶性胆道梗阻 胆管支架置入术 胰腺炎

河南省开封市科技发展计划项目

2103018

2024

10.7619/jcmp.20232989

实用临床医药杂志
扬州大学,中国高校科技期刊研究会

实用临床医药杂志

CSTPCD
影响因子：1.543
ISSN：1672-2353
年,卷(期)：2024.28(5)
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