Influencing factors and construction of risk prediction model of malnutrition in patients with gastric cancer undergoing chemotherapy
Objective To analyze the risk factors of malnutrition in patients with gastric cancer undergoing chemotherapy and construct a nomogram prediction model.Methods A total of 152 pa-tients who received complete chemotherapy were selected as study subjects.After complete chemother-apy,the patients were divided into well-nourished group(n=46)and undernourished group(n=106)according to the nutritional evaluation results.Logistic regression analysis was used to screen the influencing factors of malnutrition in patients with gastric cancer undergoing chemotherapy.A nomo-gram model was constructed to predict the risk of malnutrition in patients with gastric cancer undergo-ing chemotherapy.Receiver operating characteristic(ROC)curve and calibration curve were used to verify the differentiation and consistency of the nomogram model.Results Among 152 patients with gastric cancer treated with chemotherapy,106 were malnourished,the incidence rate was 69.74％.Male(95％CI,1.232 to 6.292,P=0.014),no parenteral nutrition support during chemotherapy(95％CI,1.528 to 7.781,P=0.003),hypoproteinemia(95％CI,1.193 to 76.786,P=0.033),early satiety(95％CI,1.259 to 82.652,P=0.030)were independent risk factors for malnutrition in patients with gastric cancer undergoing chemotherapy.The area under ROC curve was 0.757(95％CI,0.680 to 0.833).The slope of calibration curve was close to 1,and the Hosmer-Lemeshow goodness of fit test was good(x2=5.834,P=0.442).Conclusion Male,lack of parenteral nutrition support during chemotherapy,hypoproteinemia and early satiety are independent risk factors for malnutrition in patients with gastric cancer undergoing chemotherapy.The prediction nomogram model built on this basis has good differentiation and consistency.
gastric cancerchemotherapymalnutritioninfluencing factorsnomogram pre-diction model
万方数据
维普
