Efficacy observation of dulaglutide combined with insulin glargine in treating patients with type 2 diabetes mellitus
Objective To investigate the effects of dulaglutide combined with insulin glargine on glucose and lipid metabolism,pancreatic islet function,oxidative stress and bone metabolism indica-tors in patients with type 2 diabetes mellitus.Methods A total of 98 patients with type 2 diabetes mellitus were randomly divided into insulin glargine group and combined group,with 49 cases in each group.The insulin glargine group was treated with insulin glargine and metformin,while the com-bined group was treated with dulaglutide,insulin glargine and metformin.The levels of blood glu-cose,blood lipids and pancreatic islet function were compared between the two groups before and after treatment;enzyme immunoassay analyzer was used to detect the levels of oxidative stress indicators;immunoturbidimetry was used to detect bone metabolism indicators;the urinary microalbumin to creat-inine ratio(UACR)was calculated in both groups,and the therapeutic effect was compared between the two groups.Results After treatment,the levels of fasting plasma glucose(FPG),2-hour post-prandial glucose(2 hPG)and glycated hemoglobin(HbA1c)in the combined group were significantly lower than those in the insulin glargine group(P＜0.05).After treatment,the levels of total cholesterol(TC),triglycerides(TG)and low-density lipoprotein cholesterol(LDL-C)in the combined group were significantly lower than those in the insulin glargine group,while the level of high-density lipo-protein(HDL)was significantly higher than that in the insulin glargine group(P＜0.05).After treatment,the homeostatic model assessment of insulin secretion(HOMA-IS)in the combined group was significantly higher than that in the insulin glargine group,while the homeostatic model assess-ment of insulin resistance(HOMA-IR)was significantly lower than that in the insulin glargine group(P＜0.05).After treatment,the levels of catalase(CAT)and osteocalcin(OC)in the combined group were significantly higher than those in the insulin glargine group,while the levels of lipid per-oxide(LPO)and β-collagen degradation products(β-CTX)were significantly lower than those in the insulin glargine group(P＜0.05).After treatment,the UACR in the combined group was(33.26±3.37)mg/g,which was significantly higher than(25.49±2.83)mg/g in the insulin glargine group(P＜0.05).The total effective rate in the combined group was 93.88％,which was significantly higher than 79.59％in the insulin glargine group(P＜0.05).Conclusion Dulaglu-tide combined with insulin glargine can effectively regulate the blood glucose and lipid levels of pa-tients with type 2 diabetes,improve the function of pancreatic islets,alleviate the oxidative stress re-action,improve bone metabolism,and regulate the UACR level.
type 2 diabetesdulaglutideinsulin glargineglycolipid metabolisminsulin resistance indexβ-collagen degradation productsurinary microalbumin-to-creatinine ratio
万方数据
维普
