Relationships of serum levels of B-type natriuretic peptide and insulin-like growth factor binding protein-3 with atrial fibrillation in patients with non-alcoholic fatty liver disease
Objective To investigate the relationships of serum levels of B-type natriuretic pep-tide(BNP)and insulin-like growth factor binding protein-3(IGFBP-3)with the occurrence of atrial fibrillation in patients with non-alcoholic fatty liver disease(NAFLD).Methods A total of 105 pa-tients with NAFLD were included in observation group,and another 105 healthy individuals were in-cluded in control group.Clinical data of the patients were collected,and serum levels of BNP and IGFBP-3 were compared between the two groups.The influencing factors of atrial fibrillation in pa-tients with NAFLD were analyzed,and the interactive effects of serum BNP and IGFBP-3 on the risk of atrial fibrillation in patients with NAFLD were explored.The predictive value of serum BNP and IGFBP-3 levels for atrial fibrillation in patients with NAFLD was also evaluated.Results The serum levels of BNP and IGFBP-3 in the observation group were significantly higher than those in the control group(P＜0.05).Among the patients in the observation group,30 cases developed atrial fibrillation within one year.The levels of body mass index(BMI),triglycerides(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),BNP,and IGFBP-3 were higher in patients with atrial fibrillation compared to those without,while the level of high-density lipoprotein cholesterol(HDL-C)was lower(P＜0.05).BMI,TC,TG,HDL-C,LDL-C,BNP,and IGFBP-3 were all influencing factors for the occurrence of atrial fibrillation in patients with NAFLD(P＜0.05).There was an inter-action between BNP and IGFBP-3,50.47％of the risk of atrial fibrillation in patients with NAFLD was attributed to this interaction.The area under the curve for the combined prediction of serum BNP and IGFBP-3 was 0.928,which was significantly larger than the AUC of 0.753 and 0.821 for the individu-al predictions of BNP and IGFBP-3,respectively(P＜0.05).Conclusion The expression levels of BNP and IGFBP-3 in the serum of patients with NAFLD are significantly elevated,and the combined use of these markers can effectively predict the occurrence of atrial fibrillation in these patients.
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