Objective To observe the application effect of therapeutic communication combined with WeChat intervention in patients with laryngoscopic examination.Methods A total of 220 pa-tients with laryngoscopic examination were selected,and were randomly divided into control group re-ceiving routine interventions and observation group receiving therapeutic communication and WeChat intervention,with 110 cases in each group.The mood status,compliance,patient's satisfaction de-gree,and adverse reactions were compared between two groups.Results Before intervention,there were no significant differences in depression-dysphoria,confusion-disorientation,fatigue-sluggish-ness,anger-hostility,energy-vitality and tension-anxiety between the two groups(P>0.05);after the intervention,these scores in the observation group were significantly lower than those in the con-trol group(P<0.05).The observation group demonstrated significant higher compliance scores in re-examination,nursing and treatment compared to the control group(P<0.05).Before interven-tion,there were no significant differences in scores of communication and health education,nursing techniques,nursing attitudes,and examination environment between the two groups(P>0.05);af-ter intervention,the observation group showed significant higher scores of items mentioned above than the control group(P<0.05).The incidence of adverse reactions was 1.82%(2 cases)in the ob-servation group,which was significantly lower than 8.18%(9 cases)in the control group(P<0.05).Conclusion Application of therapeutic communication combined with WeChat intervention can improve mood states and compliance of patients with laryngoscopic examination,enhance patient's satisfaction degree,and reduce adverse reactions.