Iron metabolism plays a regulatory role in various metabolic diseases,and excessive iron accumulation can increase the risk of metabolic diseases,especially type 2 diabetes mellitus(T2DM).Pathological processes such as iron deposition,iron overload,and ferroptosis can activate oxidative stress,lipid peroxidation,autophagy,and other processes,promote the amplification of in-flammatory reactions and the reduction of antioxidant capacity,gradually decline the function of pan-creatic islet β-cells,thereby promoting the occurrence and development of T2DM.Glucagon-like pep-tide-1(GLP-1)is a physiological hormone secreted by intestinal L cells.GLP-1 analogs or GLP-1 receptor agonists can regulate the body's iron metabolism process,inhibit iron deposition,iron over-load,and ferroptosis-related inflammatory reactions,promote the proliferation and differentiation of pancreatic isletβ-cells,thereby reducing insulin resistance,inhibiting endothelial cell damage,and playing an important role in the prevention and treatmentof T2DM and its complications.
关键词
铁代谢/胰岛β细胞/糖尿病/慢性并发症/胰高血糖素样肽-1/胰岛素抵抗
Key words
iron metabolism/pancreatic islet β-cells/diabetes mellitus/chronic complica-tions/glucagon-like peptide-1/insulin resistance
维普
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