Research progress of anti-neutrophil cytoplasmic antibody associated vasculitis
Anti-neutrophil cytoplasmic antibody(ANCA)associated vasculitis(AAV)is a class of autoimmune diseases characterized by inflammation of the small vessel wall and fibrinoid necrosis that can involve multiple systems throughout the body.AAV in the Asian region is mainly character-ized by microscopic poly angitis(MPA),which most commonly affects the kidneys and lungs.In re-cent years,it has been discovered that complement such as C5a plays an important role in the patho-genesis of AAV through alternative pathways.Therefore,understanding the relationship between AAV complement and coagulation processes is beneficial for identifying therapeutic targets from the per-spective of pathogenesis.This review summerized the research progress on the changes in coagulation and fibrinolysis systems and their interactions with the complement system in the pathogenesis of AAV.
anti-neutrophil cytoplasmic antibodiesassociated vasculitiscomplementscoag-ulationfibrinolytic system
万方数据
维普
