慢性阻塞性肺疾病患者焦虑与脑功能活动异常的相关性研究
Correlation between anxiety symptoms and abnormal brain function in chronic obstructive pulmonary disease
马洪鸽 1王龙龙 1成莎 1王亮亮 2高延忠 1马静文 1李娜 1王警建 1李小娥3
作者信息
- 1. 陕西省西安市第九医院医学影像中心,陕西西安,710054
- 2. 陕西省西安市第九医院呼吸与危重症医学科,陕西西安,710054
- 3. 陕西省西安市第九医院药剂科静脉配液中心,陕西西安,710054
- 折叠
摘要
目的 分析慢性阻塞性肺疾病(COPD)患者长期慢性低氧状态下的焦虑症状与脑功能活动异常的相关性.方法 前瞻性选择21例COPD合并焦虑患者为COPD组,并选取26例性别、年龄相匹配的健康人群为对照组.2组患者均行高分辨率3D-T1加权成像(3D-T1WI)、T2-液体衰减反转恢复(T2-FLAIR)及血氧水平依赖(BOLD)序列检查,应用DPARSF及SPM8软件对2组脑低频振幅(ALFF)值进行分析.结果 COPD组患者左海马旁回-扣带回ALFF值增高,右额上回ALFF值减低,差异有统计学意义(P＜0.05);Pearson相关性分析发现,右额上回ALFF值与焦虑评分呈负相关(r=-0.485,P=0.03).结论 COPD慢性低氧患者存在右额上回的脑功能活动损害,损害程度与焦虑症状呈正相关,并且可能存在海马旁回-扣带回的脑功能活动代偿性增强.
Abstract
Objective To analyze the correlation between anxiety symptoms and abnormal brain function in patients with chronic obstructive pulmonary disease(COPD)under long-term chronic hy-poxia.Methods Twenty-one patients with COPD complicated with anxiety were prospectively select-ed as COPD group,and 26 healthy individuals matched for gender and age were selected as control group.Both groups underwent high-resolution 3D-T1-weighted imaging(3D-T1WI),T2-fluid-attenua-ted inversion recovery(T2-FLAIR),and blood oxygen level dependent(BOLD)sequence examina-tion.DPARSF and SPM8 software were used to analyze the amplitude of low-frequency fluctuations(ALFF)in the brain of the two groups.Results In the COPD group,the ALFF value in the left parahippocampal gyrus-cingulate gyrus increased,and the ALFF value in the right superior frontal gy-rus decreased(P＜0.05).Pearson correlation analysis found that there was a negative correlation be-tween the ALFF value in the right superior frontal gyrus and the anxiety score(r=-0.485,P=0.03).Conclusion Chronic hypoxic patients with COPD have brain functional impairment in the right superior frontal gyrus,and the degree of impairment is positively correlated with anxiety symp-toms.There may also be compensatory enhancement of brain function activity in the parahippocampal gyrus-cingulate gyrus.
关键词
慢性阻塞性肺疾病/低氧/焦虑/磁共振成像/血氧水平/低频振幅Key words
chronic obstructive pulmonary disease/hypoxia/anxiety/magnetic resonance ima-ging/blood oxygen level/low-frequency amplitude引用本文复制引用
基金项目
陕西省西安市科技计划(22YXYJ0055)
出版年
2024
国家科技期刊平台
NSTL
万方数据