The impact of different dosages of statins in elderly patients with ST-segment elevation acute myocardial infarction undergoing percutaneous coronary intervention
Objective To investigate the effects of different dosages of atorvastatin,rosuvastatin,and simvastatin in elderly patients with ST-segment elevation acute myocardial infarction(STEMI)undergoing percutaneous coronary intervention(PCI).Methods A total of 180 patients with STEMI undergoing PCI were prospectively selected as study subjects and divided into group A,group B,group C,group D,group E,and group F using a random number table method,with 30 patients in each group.The group A received low-dose simvastatin orally,the group B received high-dose simv-astatin orally,the group C received low-dose atorvastatin orally,the group D received high-dose atorv-astatin orally,the group E received low-dose rosuvastatin orally,and the group F received high-dose rosuvastatin orally.The levels of serum inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),high-sensitivity C-reactive protein(hs-CRP)],myocardial injury markers[crea-tine kinase isoenzyme(CK-MB),cardiac troponin T(cTnT),N-terminal pro-brain natriuretic pep-tide(NT-proBNP)],cardiac function indicators[left ventricular ejection fraction(LVEF),cardiac index(CI),cardiac output(CO)],as well as the ST-segment resolution,occurrence of adverse cardiovascular events,and adverse reactions were compared among the groups.Results At 1 day and 1 month postoperatively,the levels of IL-6,hs-CRP,and TNF-α decreased successively in groups A,B,C,D,E,and F(P＜0.05).At 1 day and 1 month postoperatively,the levels of cTnT,CK-MB,and NT-proBNP also decreased successively in the groups A,B,C,D,E,and F(P＜0.05).At1 month postoperatively,the LVEF,CO,and CI increased successively in the groups A,B,C,D,E,and F(P＜0.05).The proportions of patients with ST-segment resolution successively increased in the groups A,B,C,D,E,and F(P＜0.05).There were no statistically significant differences in the total incidence of adverse cardiovascular events and adverse reactions among the groups(P＞0.05).Conclusion Both low-dose and high-dose atorvastatin,rosuvastatin,and simvastatin can effectively relieve inflammation reactions,improve myocardial function,and promote ST-segment resolution in elderly patients with STEMI undergoing PCI,with high-dose rosuvastatin showing the best effect.
万方数据
维普
